Friday, March 23, 2012

Stroke risk lower among women who drink moderately: study

(Reuters) - Women who drink up to seven glasses of wine or beer a week are slightly less likely to suffer a stroke than those who steer clear of alcohol, according to a U.S. study that covered thousands of women for nearly 30 years.

The results, published in the journal Stroke, fall in line with guidelines from the American Heart Association that recommend women have no more than one drink a day -- but that doesn't mean people should take up drinking to stave off strokes, researchers said.

"We do not encourage women who do not currently drink to initiate drinking," said Monik Jimenez, a researcher at Brigham and Women's Hospital in Boston, who led the study.

"Alcohol is a double-edged sword, because higher levels can increase high blood pressure and atrial fibrillation, which are risk factors for stroke as well," she told Reuters Health.

Several previous reports have shown that low levels of alcohol drinking are tied to a smaller chance of having a stroke.

Jimenez and her colleagues used data from the massive Nurses' Health Study, which tracked the health, diet and lifestyle of more than 83,000 middle-aged women for 26 years.

They compared the drinking habits of women in the study who had had a stroke, to women who hadn't, dividing the women into five categories: from those who never drank, to the heaviest drinkers who had at least two and a half beers or two shots' worth of hard liquor or about three glasses of wine a day.

Of the roughly 25,000 women who never drank, about four percent had a stroke at some point during the study.

In contrast, two percent of the more than 29,000 women who had up to half a drink a day on average had a stroke. And of those downing between a half glass and a full glass daily, just one in 200 ended up suffering a stroke.

After the researchers took into account certain risk factors for stroke, such as smoking, being overweight and a history of heart disease, they found that having up to one drink a day was linked to a 17 to 21 percent lower chance of having a stroke.

The study didn't prove that alcohol prevented the strokes, and there's no known explanation for the relationship between the two.

It may have something to do with socioeconomic status, said Cheryl Bushnell of Wake Forest Baptist Medical Center, who was not involved in the study and noted that lower socioeconomic status is known to be linked with a higher risk of stroke and cardiovascular disease.

"My thought is that alcohol costs money. And I think that people who may be drinking light to moderate amounts with a meal are basically people who may have slightly higher means to buy that," Bushnell told Reuters Health.

"It's something that's a lifestyle."

But she did say that it's possible alcohol itself is responsible for the lower stroke risk. Jimenez suggested that alcohol might do so by preventing blood clots or altering cholesterol levels.

Her study did not show an increased risk of stroke among the women who drank the most, but other research has suggested that possibility. One found that having several drinks was actually linked to an increased risk of stroke in the next 24 hours. SOURCE: http://bit.ly/GGh2Xz

(Reporting from New York by Kerry Grens at Reuters Health; editing by Elaine Lies)

Source: http://news.yahoo.com/stroke-risk-lower-among-women-drink-moderately-study-011615709.html

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Facebook photos go high-resolution

10 hrs.

Now, more than ever, you'll want to be extra picky?about the photos you post on Facebook: ?we're not just talking crazy party photos, but those close-up shots of you and yours, no matter how crazy or sweet. That's because Facebook said Thursday it has made some "enhancements" to its photo viewer including high-resolution photos, that on a large display, can be "up to 4 times bigger than before."

That means zits et al will appear in their inglorious truth (although some people already Photoshop anything they put on the social networking site).

Photos now will "automatically" be shown in the "highest resolution possible," Facebook said in an announcement.?

And if you really want to analyze and scrutinize others' photos, you now can also expand a photo "to take up your entire computer screen," if you're using the newest versions of the Firefox or Chrome Web browsers. All you have to is click the arrows at the top-right corner of a photo to expand it to fullscreen.?

Those of you who are interested in photography itself can learn even more about the details on Facebook's Engineering page. And if you want to know more about tools you can use to make your photos look better (other than Photoshop), visit Facebook's Photo Viewer page in the Help Center.

Check out Technolog, Gadgetbox, Digital Life and In-Game on?Facebook,?and on Twitter, follow Suzanne Choney.

Source: http://www.gadgetbox.msnbc.msn.com/technology/gadgetbox/facebook-photos-go-high-resolution-522775

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Thursday, March 22, 2012

Home buying much cheaper than renting - West Chester Real Estate ...

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Honolulu is the nation?s best market to be a renter rather than a buyer.

NEW YORK (CNNMoney) ? It?s the eternal question in real estate: Should I buy or rent?

The answer has never been clearer: Buy.

In 98 of the top 100 housing markets, buying a home is more affordable than renting, according to the online real estate company Trulia. Only Honolulu and San Francisco buck the trend.

There are several reasons. Home prices are falling. Mortgage interest rates are at historically low levels. And rents are on the rise.

Of course, many renters are not in a position to buy. For one, it?s hard to get a mortgage these days, despite low rates. And paying rent can push them further away from being able to afford to buy.

?Rising rents make it harder for people to save for a down payment, which is the biggest barrier to buying a home that aspiring homeowners face,? Jed Kolko, Trulia?s chief economist.

The nation?s cheapest buyer?s market is Detroit, where purchasing is only 3.7 times more expensive than renting.

Other top five metro areas where buying is much better than renting are Oklahoma City, Dayton, Ohio,Warren, Mich. and Toledo, Ohio.

Rankings like these, however, can obscure the factors that go into each decision.

Housing markets, even within a single metro area, typically have local submarkets. Take New York City, for example. Renting in Manhattan is more affordable than buying. But in suburban Westchester County just miles to the north, buying is the more affordable option.

The size of the home can also make a difference. In some markets, renting can be a better deal on larger homes, according to Trulia.

Readers on mortgage settlement: This stinks

In San Francisco, for example, studio and one-bedroom apartments sell for 13.1 times rent, while three bedrooms or larger sell for more than 18 times rent.

The Trulia survey does not take into account home price trends, which are another factor for individuals choosing whether to buy or rent.

?People will pay more for a home if they expect prices to rise and give them a better return on their investment,? said Kolko.

Those calculations are about to change, according to Ken H. Johnson, a professor of real estate at Florida International who has studied the buy-vs-rent question extensively. He believes home prices nationally have bottomed.

?The ship has turned,? he said. ?Markets should slowly start to recover. Housing will return to its traditional role of a safety investment.?

If so, that adds an incentive to buy. And investing in many of the most expensive markets may be even safer.

Foreclosures: A rising tide ahead

Kolko pointed out that places like Honolulu, San Francisco and Boston have strong long-term growth prospects. They also have little physical space to grow, a factor that tends to keep prices strong.

On the other hand, old areas that aren?t growing much ? while cheap ? may not return much in the long run.

?Buying is much cheaper than renting in slow-growing places with high vacancy rates and land to spare, like Detroit and Cleveland, where prices are unlikely to improve much in the future,? he said.?a1b37 bug Home buying much cheaper than renting

Article source: http://money.cnn.com/2012/03/21/real_estate/homes-buy-rent/?source=cnn_bin

Source: http://westchesterrealestateinformation.com/home-buying-much-cheaper-than-renting-3/

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Massachusetts Nonprofit Network ? Business Briefcase: Nominate ...

March 20th, 2012

Gloucester Times

BOSTON ? The Massachusetts Nonprofit Network (MNN), a statewide organization that works to strengthen and raise the profile of the state?s nonprofit sector, has opened nominations for the fourth annual Nonprofit Excellence Awards. The awards recognize the work of exceptional nonprofits and nonprofit leaders in communities across the state.

?Nonprofits touch every part of our lives,? said Rick Jakious, chief executive officer of MNN. ?This is an opportunity to recognize the nonprofits that make a unique contribution in your community.?

The Nonprofit Excellence Awards will be presented at MNN?s celebration of Nonprofit Awareness Day at the State House on June 11.

Nomination deadline is March 28. Full descriptions of the awards and nomination forms are available on the Massachusetts Nonprofit Network website: http://bit.ly/2012MNNExcellenceAwards.


Source: http://www.massnonprofitnet.org/mnn-news/business-briefcase-nominate-nonprofits-for-awards/

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Tuesday, March 20, 2012

Discovery provides blueprint for new drugs that can inhibit hepatitis C virus

Tuesday, March 20, 2012

Chemists at the University of California, San Diego have produced the first high resolution structure of a molecule that when attached to the genetic material of the hepatitis C virus prevents it from reproducing.

Hepatitis C is a chronic infectious disease that affects some 170 million people worldwide and causes chronic liver disease and liver cancer. According to the Centers for Disease Control and Prevention, hepatitis C now kills more Americans each year than HIV.

The structure of the molecule, which was published in a paper in this week's early online edition of the journal Proceedings of the National Academy of Sciences, provides a detailed blueprint for the design of drugs that can inhibit the replication of the hepatitis C virus, which proliferates by hijacking the cellular machinery in humans to manufacture duplicate viral particles.

Finding a way to stop that process could effectively treat viral infections of hepatitis C, for which no vaccine is currently available. But until now scientists have identified few inhibiting compounds that directly act on the virus's ribonucleic acid (RNA) genome?the organism's full complement of genetic material.

"This lack of detailed information on how inhibitors lock onto the viral genome target has hampered the development of better drugs," said Thomas Hermann, an associate professor of chemistry and biochemistry at UC San Diego who headed the research team, which also included scientists from San Diego State University. The team detailed the structure of a molecule that induces the viral RNA to open up a portion of its hinge-like structure and encapsulate the inhibitor like a perfectly fit glove, blocking the ability of the hepatitis C virus to replicate.

The molecule is from a class of compounds called benzimidazoles, known to stop the production of viral proteins in infected human cells. Its three-dimensional atomic structure was determined by X-ray crystallography, a method of mapping the arrangement of atoms within a crystal, in which a beam of X-rays strikes a crystal and causes the beam of light to spread. The angles and intensities of the light beams allowed the scientists to calculate the structure of the viral RNA-inhibitor complex.

"This structure will guide approaches to rationally design better drug candidates and improve the known benzimidazole inhibitors," said Hermann. "Also, the crystal structure demonstrates that the binding pocket for the inhibitors in the hepatitis C virus RNA resembles drug-binding pockets in proteins. This is important to help overcome the notion that RNA targets are so unlike traditional protein targets that drug discovery approaches with small molecule inhibitors are difficult to achieve for RNA."

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University of California - San Diego: http://www.ucsd.edu

Thanks to University of California - San Diego for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/118549/Discovery_provides_blueprint_for_new_drugs_that_can_inhibit_hepatitis_C_virus

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NPT Jobs: Development jobs, Foundation jobs, Philanthropic ...

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Source: http://careercenter.nptimes.com/jobs/4706827/president

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